Resveratrol 

Resveratrol is a naturally occurring polyphenol possesses anti-inflammatory, anti-tumorigenic, and antioxidant properties, which may be harnessed in strategies against chronic diseases.

Studies on the health benefits of Resveratrol have reported a reduction in age-associated symptoms and the prevention of early mortality in obese animals [2,3,4].
 
The life expectancy of some small organisms has been extended by Resveratrol via the stimulation of caloric restriction [5] and the delay of specific age-related phenotypes, e.g., abnormal glucose metabolism [6]. RV is also associated with a slowing down or prevention of cognitive deterioration [7].

The potential mechanisms of action responsible for the health effects of Resveratrol are numerous [1]. Resveratrol triggers the expression of a wide range of antioxidant enzymes, determining the contribution of each mechanism to an overall decrease in oxidative stress is a complex task [8]. Additionally, a large number of receptors, kinases, and other enzymes

Resveratrol is a daily supplement that activates the Sirtuin longevity genes (a family of genes that play a major role in repairing DNA).

Resveratrol has become popular due to David Sinclair’s research, a Professor of Genetics at Harvard University. David describes Resveratrol as critical for the activation of the Sirtuin genes. Sirtuins play a key role in functions that help us to live longer – such as DNA repair. In effect, you take resveratrol to increase activation of the Sirtuin genes, and NMN to ensure the Sirtuins have enough NAD to work properly.

Resveratrol is Fat Soluble - without fat the absorption of Resveratrol is 5x lower. It is recommended to take Resveratrol mixed with yogurt or other foods containing fat!  Resveratrol has been shown to increase the healthy lifespan of mammals by up to 30%

This powerful antioxidant contains the highest quality Resveratrol powder, which is derived from plants including the most potent source:  Japanese Knotweed
 
Key Benefits Resveratrol:
 

• Powerful Antioxidant

• Helps decrease free radical damage to cells

• Maintains Cardiovascular system function and health

• Reduce inflammation and decrease exercise recovery time

• Increased energy and endurance

• Maintain and enhance skin health for a more youthful appearance

• Enhance cognitive function

 
Resveratrol is known for its power to neutralise damaging free radicals that lead to signs of aging and disease as well as its ability to activate sirtuin proteins in our cells. It can be supplemented with an NAD precursor, such as NMN, to optimise energy.

 

 

Natural Vs. Synthetic Resveratrol

 

Resveratrol is sourced naturally from Japanese knotweed, yeast fermentation and grape extracts. These sources constitute Natural Resveratrol.

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Top quality Natural Resveratrol has a purity of around the 98% mark, whilst Synthetic Resveratrol has a purity of above 99%, sometimes as high as 99.9% as this is man made and produced in a lab.

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Synthetic Resveratrol is chemically produced using a four-step decarbonylative process known as the Heck reaction. Though the result is a resveratrol compound, the yields have been poor, leading to several studies and experiments to discover ways to increase the output. 

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Resveratrol is becoming so popular that more and more companies are producing synthetic resveratrol in labs, factories, and manufacturing bases. Some export enterprises without morality sell synthetic resveratrol under the name of natural resveratrol as Polygonum Cuspidatum Extract or giant Knotweed Extract. Some even mix synthetic resveratrol 99% into the low spec resveratrol to make up the 50% resveratrol.

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Why so many companies are doing this? The answer is profit. It is greed that pushes those companies to commit fraud. The bulk price for Natural Resveratrol 98% is ALMOST 50% more expensive than the price for Synthetic Resveratrol.

We do know that most of the Synthetic Resveratrol have the contaminants 3,5-dimethoxybenzaldehyde; Aluminium(II)chloride; 4--Hydroxyphenylacetic acid;Acetic anhydride; Triethylamine and (E )-2(4-Hydroxyphenyl)-3-(3,5- dihydroxyphenyl) acrylic acid.

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Cis-resveratrol and Trans-resveratrol are the two forms of Resveratrol found in Natural Resveratrol powders.

Trans-resveratrol is the active form that humans are able to absorb, while the Cis-resveratrol is inactive. The proportion of Cis-Resveratrol in Synthetic Resveratrol powder is much higher than that of Natural Resveratrol Powder.

 

Synthetic Resveratrol contains large amounts of Chloridion, furthermore the age of carbon in the synthetic resveratrol is more than thousand years old, extracted from petroleum or fossil. While the carbon of Natural Resveratrol is absorbed from water, sun and by the plant itself & the age is within one or two years. This is the best and recommended way. In addition, research indicates that trans-resveratrol the form found in natural sources is more bioactive and preferred to the synthetic cis- sources.

 
 
REFERENCES
 
1. Baur J.A., Pearson K.J., Price N.L., Jamieson H.A., Lerin C., Kalra A., Prabhu V.V., Allard J.S., Lopez-Lluch G., Lewis K., et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337–342. doi: 10.1038/nature05354. 
2. Miller R.A., Harrison D.E., Astle C.M., Baur J.A., Boyd A.R., de Cabo R., Fernandez E., Flurkey K., Javors M.A., Nelson J.F., et al. Rapamycin, but not resveratrol or simvastatin, extends life span of genetically heterogeneous mice. J. Gerontol. Ser. A Biol. Sci. Med. Sci. 2011;66:191–201. doi: 10.1093/gerona/glq178. 
3. Pearson K.J., Baur J.A., Lewis K.N., Peshkin L., Price N.L., Labinskyy N., Swindell W.R., Kamara D., Minor R.K., Perez E., et al. Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending lifespan. Cell Metab. 2008;8:157–168. doi: 10.1016/j.cmet.2008.06.011. 
4. Barger J.L., Kayo T., Vann J.M., Arias E.B., Wang J., Hacker T.A., Wang Y., Raederstorff D., Morrow J.D., Leeuwenburgh C., et al. A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE. 2008;3:e2264. doi: 10.1371/annotation/c54ef754-1962-4125-bf19-76d3ec6f19e5. 
5. Baur J.A., Sinclair D.A. Therapeutic potential of resveratrol: The in vivo evidence. Nat. Rev. Drug Discov. 2006;5:493–506. doi: 10.1038/nrd2060. 
6. Poulsen M.M., Vestergaard P.F., Clasen B.F., Radko Y., Christensen L.P., Stødkilde-Jørgensen H., Møller N., Jessen N., Pedersen S.B., Jørgensen J.O.L. High-dose resveratrol supplementation in obese men: An investigator-initiated, randomized, placebo-controlled clinical trial of substrate metabolism, insulin sensitivity, and body composition. Diabetes. 2013;62:1186–1195. doi: 10.2337/db12-0975. 
7. Ranney A., Petro M.S. Resveratrol protects spatial learning in middle-aged C57BL/6 mice from effects of ethanol. Behav. Pharmacol. 2009;20 doi: 10.1097/FBP.0b013e32832f0193. 
8. Halliwell B. Dietary polyphenols: Good, bad, or indifferent for your health? Cardiovasc. Res. 2007;73:341–347. doi: 10.1016/j.cardiores.2006.10.004.