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NMN (Nicotinamide Mononucleotide)

Potential Benefits Of NMN That Are Backed by Science

In June of 2018, the World Health Organization (WHO) released the 11th edition of its International Classification of Diseases, and for the first time added aging.1
 
Nutrient sensing systems have been an intense focus of investigation, including mTOR (the mammalian target of rapamycin) for regulating protein synthesis and cell growth; AMPK (activated protein kinase) for sensing low energy states; and sirtuins, a family of seven proteins critical to DNA expression and aging, which can only function in conjunction with NAD+ (nicotinamide adenine dinucleotide), a coenzyme present in all living cells.4
 
The slow process of aging has been described as a “cascade of robustness breakdown triggered by a decrease in systemic NAD+ biosynthesis and the resultant functional defects in susceptible organs and tissues.”6 Aging is marked by epigenetic shifts, genomic instability, altered nutrient sensing ability, telomere attrition, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and dysregulated intercellular communication.7,8
 
By middle age, our NAD+ levels have plummeted to half that of our youth.9 Numerous studies have demonstrated that boosting NAD+ levels increases insulin sensitivity, reverses mitochondrial dysfunction, and extends lifespan.10,11 NAD+ levels can be increased by activating enzymes that stimulate synthesis of NAD+, by inhibiting an enzyme (CD38) that degrades NAD+, and by supplementing with NAD precursors, including nicotinamide riboside(NR) and nicotinamide mononucleotide (NMN).12,13 
 
A conceptual framework called NAD World, formulated over the last decade by developmental biologist Shin-ichiro Imai, MD, PhD, of Washington University School of Medicine, positions NMN as a critical, systemic signaling molecule that maintains biological robustness of the communication network supporting NAD+.6
 
NMN has been able to suppress age-associated weight gain, enhance energy metabolism and physical activity, improve insulin sensitivity, improve eye function, improve mitochondrial metabolism and prevent age-linked changes in gene expression.14
 
NMN Nicotinamide Mononucleotide is a NAD precursor and Sirtuin activator, the body’s anti-aging and longevity genes, so you may look and feel years younger. NMN also promotes new cellular growth and restores mitochondrial function to assist in fast recovery of muscle tissue and the immune system.
 
Key Benefits of NMN:
 

  • Increase NAD levels (NAD is an essential molecule in every cell, without which we cannot survive)

  • Mimics the effect of exercise to assist in prevention of weight gain

  • Improve cognitive impairment

  • Restored growth of new blood vessels for improved circulation and reversal of vascular atrophy

  • Boost Immunity & Immune System Health

  • Powerful Anti-Aging Support

  • Promotes DNA Repair Through SIRTUIN Gene Activation

  • Supports Cardiovascular Health

  • Enhance Cognitive Function

  • Boost Energy Levels, Metabolism & Endurance

  • Helps Reduce Stress & Fatigue

  • Effectively Increases NAD+ Levels which:

    • Helps Breakdown of Foods Like Sugars Into Energy

    • Promote Healthy Cardiovascular Function

    • DNA Repair - NAD+ is used to repair broken DNA strands

    • SIRTUIN Activator - NAD+ is required for our longevity genes to work.


Green As Nature NMN formula is:

​

  1. GMP (Good Manufacturing Practice) Certified

  2. >99.5% Purity

  3. No Added Fillers or Binders

  4. No Artificial Ingredients 


References:
 

1. Zhavoronkov A, et al. Classifying aging as a disease in the context of ICD-11. Front Genet. 2015. November 
2. Blagosklonny MV. Disease or not, aging is easily treatable. Aging (Albany NY). 2018. November 17;10(11):3067-3078  
3. Editorial. Opening the door to treating ageing as a disease. Lancet Diabetes Endocrinol. 2018. August;6(8):587. 
4. López-Otín C, et al. The hallmarks of aging. Cell 2013;153(6):1194-1217 [PMC free article] [PubMed] [Google Scholar]
5. Schultz MB, et al. Why NAD+ Declines during Aging: It’s Destroyed. Cell Metab. 2016. June 14; 23(6): 965–966 
6. Imai S. The NAD World 2.0: the importance of the inter-tissue communication mediated by NAMPT/NAD+/SIRT1 in mammalian aging and longevity control. NPJ Syst Biol Appl. 2016. August 18;2:16018. 
7. Conboy IM, et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005; 433: 760–764. 
8. de Magalha~es JP, et al. Meta-analysis of age-related gene expression profiles identifies common signatures of aging. Bioinformatics 2009: 25: 875–881. 
9. Zhu XH, et al. In vivo NAD assay revels the intracellular NAD contents and redox state in healthy human brain and their age dependences. Proc. Natl. Acad. Sci. 2015; 112:2876–2881 
10. Suave AA. NAD+ and vitamin B3: from metabolism to therapies. J Pharmacol Exp Ther. 2008. March;324(3):883-93 
11. Lee CF, et al. Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease. Sci Rep. 2019. February 28;9(1):3073. 
12. Camacho-Pereira J, et al. CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism. Cell Metab. 2016. June 14;23(6):1127-1139 [PMC free article] [PubMed] [Google Scholar]
13. Longo VD, et al. Interventions to Slow Aging in Humans: Are We Ready? Aging Cell 14(4): 497-510.

14. Mills KF, et al. Long-term administration of nicotinamide mononucleotide mitigates age-associated physiological decline in mice. Cell Metab. 2016. December 13;24(6):795-806

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